You can offer a toast to this mega-deal for its sheer audacity. And its cultural smarts.
With news that the Japanese whiskey and beer giant Suntory Holdings has agreed to purchase the maker of the legendary Jim Beam bourbon for $13.6 billion, another chunk of Americana falls into foreign hands. But, in this case, perhaps, ably so.
Suntory ��which makes Yamazaki whiskey and Premium Malt's beer ��totally gets American shtick. It was, after all, among the earliest major Asian marketers to cozy-up to American celebrities to sell stuff in Japan. Way back in the "Rat Pack" heyday of the early 1970s, no less than Sammy Davis Jr., showed up in ads for Suntory brands in Japan.
Even folks who don't have the name Suntory at the tips of their tongues, probably are familiar with actor Bill Murray, whose character in the 2003 film Lost in Translation, so perfectly depicted the image of a fading American actor seeking redemption �� and a few bucks �� overseas. His most famous line from the film: "For relaxing times, make it Suntory time."
PowerShares DWA Technical Leaders Portfolio (Fund) seeks investment results that correspond generally to the price and of an equity index called the Dorsey Wright Technical Leaders Index (the Index). The Index consists of stocks of approximately 100 United States companies that are selected pursuant to a selection methodology of Dorsey Wright & Associates (the Index Provider). The Index is designed to identify companies that demonstrate powerful relative strength characteristics. Relative strength characteristics are based upon each security�� market performance. The companies are selected from a broad mid-cap and large-cap universe.
The Fund will normally invest at least 90% of its total assets in common stocks that comprise the Index. The Index is adjusted quarterly, and the Fund, using an indexing investment approach, attempts to replicate the performance of the Index. The Fund generally will invest in the stocks comprising the Index in proportion to their weightings in the Index. The Fund�� investment advisor is PowerShares Capital Management LLC.
Advisors' Opinion: - [By Victor Selva]
Of course, a great bet also involves many risks. Even though LCD technology became very popular in these last few years, both in TV screens and computer monitors, we should never miss the fact that technological markets are often exposed to products becoming obsolete due to the development of new, more efficient technology. Without going any further, it�� easy to recall the plasma display panel (PDP) fiasco, an apparently promising market in the 1990s and early 2000s but quickly replaced by LCDs (by 2008 LCDs sell 21.1 million units, almost 10 times PDP sales on the same year). Even Panasonic Corporation (PCRFF) announced it will interrupt production of PDP on 2014.
Top Asian Stocks To Own Right Now: Internet Gold Golden Lines Ltd (IGG)
Internet Gold Golden Lines Ltd., incorporated in April 1992, is a communications services provider. The Company�� subsidiaries are B Communications Ltd. (B Communications) (formerly 012 Smile.Communications Ltd.) and GoldMind Ltd. (formerly Smile.Media Ltd.). B Communications is the controlling shareholder of Bezeq. It owns 78.11% of the interest B Communications. Bezeq is the principal provider of communications services in Israel. The Group has four areas of operation, which include Bezeq domestic fixed-line communications, Pelephone Communications Ltd., Bezeq International Ltd. and D.B.S. Satellite Services (1998) Ltd. The Company�� subsidiary, B Communications, holds 30.44% interest of Bezeq (TASE:BZEQ). On March 14, 2011, B Communications purchased additional interest in Bezeq increasing its ownership interest to 31.37%. On March 3, 2011, Partner completed its acquisition of 012 Smile.
Bezeq domestic fixed-line communications primarily includes Bezeq�� operation as a domestic operator, including telephony services, Internet services, transmission services and data communications. Pelephone Communications Ltd. provides cellular services (cellular communications), marketing of end-user equipment, installation, operation and maintenance of cellular communications equipment and systems. Bezeq International Ltd. provides international communications services, Internet access (ISP) services, and network endpoint (NEP) services. D.B.S. Satellite Services (1998) Ltd. provides multi-channel broadcast and value added services via satellite.
Bezeq fixed-line business
Bezeq's telephony services include basic telephony services on domestic telephone lines and associated services, such as voice mail, caller identity (ID), call waiting, call forwarding, speed dial, and conference calls. Bezeq also provides national services for businesses (1-800, 1-700) that offer full or partial payment for incoming calls by businesses. As of December 31, 2010, Bezeq operated about ! 12,500 public telephones around the country, which were operated by various types of pre-paid cards. Bezeq operates a unified telephone directory for fixed-line and cellular telephony operators, as well as a unified Website, which is free of charge, in addition to its 144 (directory information) service. As of December 31, 2011, Bezeq had 2,367,000 active telephone lines.
Bezeq provides broadband Internet access infrastructure services in xDSL technology. As of December 31, 2011, Bezeq had 1,111,000 Internet subscribers. Data communications services are network services for point-to-point transfer of data, transfer of data between computers and various communications networks, services to connect communications networks to the Internet, and remote access services. The companies operating in this field are Cellcom, Partner (which acquired the Med-1 operation), HOT and Internet companies that also use leased infrastructures. Bezeq offers transmission services, including high speed services, to other communications operators and to its business customers over a variety of protocols. At December 31, 2011, the percentage of Internet subscribers connected to the next generation network (NGN) was approximately 87% of Bezeq's total Internet subscribers, and the percentage of subscribers using NGN services was 48% of all Internet subscribers connected to the NGN network.
Bezeq provides services to other communications operators, including the cellular and international operators, cable broadcasting license-holders, NEP operators, ISPs, domestic operators, and Palestinian communications providers. Bezeq�� services include infrastructure, connection to Bezeq's network, transmission, billing and collection, rental of space and provision of services in its rented properties and rights of use for seabed cables. Bezeq operates and maintains radio transmitters, including those operated by the Israel Broadcasting Authority, television transmitters of Channel 1, Educational Television and Cha! nnel 2, a! nd the transmitters of regional radio stations. Bezeq also operates digital terrestrial television (DTT) transmitters. Bezeq is responsible only for operation and maintenance of the transmitters for distribution of radio and television programs, and not for the content of the broadcasts.
Bezeq performs setup and operation work on networks and sub-networks for various customers, such as the Ministry of Defense, HOT, radio and television broadcasting companies, cellular and international communication operators, local authorities, municipalities and government agencies. Bezeq and HOT have agreements for the provision of installation and maintenance services of cable networks, on Bezeq's infrastructure, from the starting point of those licensees��operating center, up to the point of delivery at the entrance to subscribers��homes. The IP Centrex service is a virtual private exchange service. Data Center service enables provision of a solution for customers from the aspects of backup and survivability. 144 Internet site is a search engine for finding business and private telephone numbers. Bezeq�� launch of its new generation network (NGN) has enabled it to offer new services, such as Bphone (a service enabling telephone calls to be made through the Internet as calls made from a fixed-line phone), on-hold music, storage services on the network and home exchange services.
Pelephone
Pelephone provides its subscribers with an offering of voice transmission, transmission of text messages, data communications and advanced multimedia services. Pelephone�� service package includes basic call services, call completion services and auxiliary services, such as call waiting, call forwarding, voice mail, voice conference call and caller ID. Pelephone offers its customers value added services, such as Internet surfing, text messaging and information services using short message service SMS (text), multimedia messaging service (MMS) messages, voice information services using ! special p! urpose asterisks, information and entertainment services through as Internet portal. Pelephone�� value added services also include the ability to watch various television channels, such as music, sports, news and entertainment channels, and the ability to photograph and forward video files.
Pelephone provides roaming services (communications by means of cellular handsets from different locations around the world) in accordance with agreements it has with cellular operators abroad, enabling Pelephone to access their networks. Pelephone offers its customers a repair service for a monthly payment entitling the customer to a warranty for the cellular handset, or for a one-time payment at the time of repair. Pelephone offers its customers various types and brands of cellular telephones, on-board telephones and hands-free devices, as well as support for its range of services. Pelephone also supplies its customers with modems and laptop computers for surfing the Internet through the Pelephone network. Pelephone provides roaming services (communications by means of cellular handsets from different locations around the world) in accordance with agreements it has with cellular operators abroad, enabling Pelephone to access their networks. The roaming tariffs are defined in the Individual Annex. Pelephone offers its customers a repair service for a monthly payment entitling the customer to a warranty for the cellular handset, or for a one-time payment at the time of repair. Pelephone offers its customers various types and brands of cellular telephones, on-board telephones and hands-free devices, as well as support for its range of services. Pelephone also supplies its customers with modems and laptop computers for surfing the Internet through the Pelephone network.
Bezeq International
Bezeq International provides communication solutions to its customers in the private and business sectors, in four areas of operation. It includes Internet access services, International tele! phony ser! vices, NEP services, and Data and Information and Communication Technology (ICT), solutions. In the voice services sector, Bezeq International provides international direct dialing (IDD), services to business and private customers; toll-free number services for business customers overseas; international call routing and termination services (hubbing) transfer of international calls between foreign communication providers (worldwide), calling card services enabling prepaid and postpaid dialing from and to Israel, for business and private customers, and the 1809 service for dialing from Israel to other countries. Bezeq International also provides domestic telephony services by means of Voice over Broadband (VOB), access.
In the Internet services sector, Bezeq International provides Internet access services for private and business customers, including terminal equipment and support, with an emphasis on broadband Internet based on asymmetric digital subscriber line (ADSL) or cable infrastructures; hosting services site storage and server services in a designated installation for business and private customers, including value-added services (such as monitoring and control); information security services, services securing customers Internet and local area network (LAN) connections using the required terminal equipment or software, including monitoring; data services with international data communication IP solutions for business customers, including global deployment if necessary, and wireless fidelity (WIFI) access fast wireless access solutions for private and business customers, including in various public locations (hotspots).
Bezeq International supplies of international data communication solutions for business customers, including customized global deployment. As part of the service contracts, Bezeq International supplies direct maintenance of a range of exchange manufacturers. The services are given to gateways, exchanges and NEP designated for use with both internal and ! external ! lines. As part of business information technology (IT) solutions, Bezeq International provides communications services, including data and overseas communication services, server and Website hosting services, technical maintenance and support services, networking and system services, outsourcing and out-tasking services, security and risk management solutions and IP based services. Bezeq also provides ICT solutions to business customers as part of an overall ICT solution for businesses. Bezeq International provides broad communications services, including international data and communication services, server and site hosting services, technical support and maintenance services, network and system services, outsourcing and out-tasking services, security and risk management solutions and managed IP services.
DBS
DBS�� broadcasts approximately 150 different video channels, of which 14 are pay-per-view (PPV) channels and 19 are high definition (HD), channels, 20 radio channels, 30 music channels and interactive services. The broadcasts include a basic package which each subscriber is required to purchase as well as additional channels chosen by the subscriber, whether as a package or as single and PPV channels. The main channel packages marketed by DBS in addition to the basic package are the movie, entertainment, children's, music, sports, science and nature packages. DBS also has a content Website which is operated together with Walla! which allows viewing of various forms of content, some of them at a fee. DBS markets personal video recorder (PVR), decoders which interface with DBS�� electronic broadcast schedule and enable receipt of special services, including ordering recordings in advance, recording series and pausing live broadcasts. DBS also provides its subscribers with HD broadcasts, which can be received through special decoders.
The Company competes with Cellcom Israel Ltd., or Cellcom, Partner. 013 Netvision, 012 Smile, 018 Xfone, HILAT Israel Telecom! municatio! ns Company Ltd., and Telzar International Communication Services Ltd.
Advisors' Opinion: - [By Alexis Xydias]
Brokerages are beating banks and the broader market in Europe. The Stoxx 600 Financial Services Index has gained 12 percent this year, more than twice the 5.6 percent advance for a gauge of European banks. Hargreaves Lansdown Plc (HL/), the U.K.�� largest retail broker, which received record cash in its latest quarter, according to an April 17 statement, advanced 33 percent. IG Group Holdings Plc (IGG), the London-based provider of spread betting, rose 30 percent.
Top Asian Stocks To Own Right Now: Rubicon Minerals Corp(RBY)
Rubicon Minerals Corporation, a mineral exploration company, engages in the acquisition, exploration, and development of mineral properties in Canada and the United States. It primarily explores for gold and base metal deposits. The company?s key asset is the Phoenix Gold Project located in the Red Lake gold camp, in the Province of Ontario. As of March 31, 2010, it controlled approximately 65,000 acres of prime exploration ground in the prolific Red Lake gold district of Ontario, Canada, as well as approximately 380,000 acres surrounding the Pogo Mine in Alaska and approximately 225,000 acres in northeast Nevada. The company was founded in 1996 and is headquartered in Vancouver, Canada.
Advisors' Opinion: - [By Sean Williams]
Another reason this fund looks attractive (at least to me) is that Rubicon Minerals (NYSEMKT: RBY ) is one of its largest holdings at 6.02% of its assets as of May 10, 2013. Rubicon is in the late stages of the development process for the F2 Gold System, which has yielded drilling assessments as high as 767 grams/ton. F2 appears to be just as bountiful in gold well below the surface as it is near the surface, which could mean a very long and profitable mine life for Rubicon.
Top Asian Stocks To Own Right Now: Aircastle Ltd (AYR)
Aircastle Limited (Aircastle), incorporated on October 29, 2004, is a global company that acquires, leases, and sells high-utility commercial jet aircraft to customers throughout the world. As of December 31, 2012, the Company's aircraft portfolio consisted of 159 aircraft that were leased to 69 lessees located in 36 countries. The Company manages its fleet through offices in the United States, Ireland and Singapore. The Company invests in aircraft that the Company places on operating or finances leases. The Company also makes investments in other aviation assets, including debt investments secured by commercial jet aircraft. The Company operates in single segment being Aircraft leases. The Company owned 133 passenger aircraft, representing approximately 71% of the net book value of flight equipment, while its 26 freighter aircraft account for 29% of its portfolio value. Effective July 12, 2013, Marubeni Corp acquired a 15.25% interest in the Company.
The Company leases its aircraft on an operating lease basis. Under an operating lease, the Company retains the benefit, and bear the risk, of re-leasing and of the residual values of the aircraft upon expiration or early termination of the lease. Under the Company's leases, the lessees agree to lease the aircraft for a fixed term, although certain of its operating leases allow the lessee the option to extend the lease for an additional term or, in rare cases, terminate the lease prior to its expiration. During the year ended December 31, 2012, the Company's three customers, Martinair , including its affiliates, KLM, Transavia and Transavia France, U.S. Airways, Inc., and Hainan Airlines Company, accounted for 9%, 6% and 6% of the Company�� revenues.
As of December 31, 2012, the Company had 19 aircraft having scheduled lease expirations in 2013 and the Company has lease or leases extension commitments for two of these aircraft. The remaining 17 aircraft with scheduled expiries in 2013. The Company entered into early termination! agreements for two Boeing Model 737-700 aircraft, one Airbus model A330-200 aircraft, one Boeing Model 767-300ER aircraft and one Airbus Model A319-100 aircraft, which the Company is marketing for sale or leases.
The Company competes with GE Commercial Aviation Services, International Lease Finance Corporation (ILFC), AerCap Holdings NV, Air Lease Corporation, Aviation Capital Group, CIT Aerospace, AWAS, SMBC Aviation Capital (formerly RBS Aviation Capital), BOC Aviation, FLY Leasing, Ltd., Avolon, Guggenheim Aviation Partners, Volito, Deucalion, Oak Hill Aviation and AerSale
Advisors' Opinion: - [By Roberto Pedone]
One commercial leasing player that insiders are active in here is Aircastle (AYR), which acquires, leases and sells high-utility commercial jet aircraft to passenger and cargo airlines throughout the world. Insiders are buying this stock into notable strength, since shares are up sharply by 52% in 2013.
Aircastle has a market cap of $1.5 billion and an enterprise value of $4.8 billion. This stock trades at a premium valuation, with a trailing price-to-earnings of 124.68. This is not a cash-rich company, since the total cash position on its balance sheet is $238.15 million and its total debt is $3.48 billion. This stock currently sports a dividend yield of 4.2%.
A director just bought 30,000 shares, or about $563,000 worth of stock, at $18.79 per share.
From a technical perspective, AYR is currently trending above both its 50-day and 200-day moving averages, which is bullish. This stock has been uptrending strong for the last five months, with shares moving higher from its low of $15.84 to its recent high of $19.50 a share. During that uptrend, shares of AYR have been consistently making higher lows and higher highs, which is bullish technical price action. That move has now pushed shares of AYR within range of triggering a big breakout trade.
If you're bullish on AYR, then I would look for long-biased trades as long as this stock is trending above its 50-day at $18.67 or above more support near $18, and then once it breaks out above its 52-week high at $19.50 a share with high volume. Look for a sustained move or close above that level with volume that hits near or above its three-month average volume of 430,032 shares. If that breakout hits soon, then AYR will set up to enter new 52-week high territory, which is bullish technical price action. Some possible upside targets off that breakout are $25 to $30 a share.
- [By Seth Jayson]
Calling all cash flows
When you are trying to buy the market's best stocks, it's worth checking up on your companies' free cash flow once a quarter or so, to see whether it bears any relationship to the net income in the headlines. That's what we do with this series. Today, we're checking in on Aircastle LTD (NYSE: AYR ) , whose recent revenue and earnings are plotted below.
- [By Vera Yuan]
We initiated a new position in Aircastle Ltd. (AYR), an aircraft leasing company with a flexible business model and a rational capital allocation philosophy. We took advantage of an opportunity to purchase shares in the heavily capitalized Georgia bank State Bank Financial Corp. (STBZ) as the depressed stock price reflected investors��lack of patience with a slower than expected pace of capital deployment. We like State Bank�� management team led by Georgia banker Joe Evans. This management team has experience successfully building and selling other Georgia banks. We also received shares of transportation infrastructure company XPO Logistics, Inc. (XPO) as a result of its acquisition of holding Pacer International, Inc.
- [By David Sterman]
As a result, many recent insider purchases are now "underwater." That spells opportunity. If these stocks are even cheaper than the levels in which insiders found them to be appealing, then we may witness even deeper insider buying in coming weeks, further validating this "buy" signal. Here's a look at six examples.
1. Aircastle (NYSE: AYR) In early June, this aircraft leasing firm agreed to sell a 15% stake in itself to Japan's Marubeni Corp. The two firms aim to leverage each other's global transport divisions, cross-selling services and equipment to each other's customer base. Marubeni began buying shares in subsequent weeks, and by early August, already qualified as an insider as its ownership stake moved above 5%. Throughout the past month, Marubeni has kept on buying, even as shares moved past the $17 mark. Yet in recent days, the market turmoil has pushed shares down close to $16. Look for Marubeni to keep buying until it hits the 15% ownership threshold. Meanwhile, analysts have yet to project the benefits of these two firms' partnership, as forward earnings estimates have remained largely static over the past 90 days.
Top Asian Stocks To Own Right Now: Matador Resources Co (MTDR)
Matador Resources Company is an independent energy company engaged in the exploration, development, production and acquisition of oil and natural gas resources in the United States, with an emphasis on oil and natural gas shale and other unconventional plays. Its operations are focused primarily on the oil and liquids-rich portion of the Eagle Ford shale play in South Texas and the Wolfcamp and Bone Spring plays in the Permian Basin in Southeast New Mexico and West Texas. The Company also operates in the Haynesville shale and Cotton Valley plays in Northwest Louisiana and East Texas. In addition, it has a large exploratory leasehold position in Southwest Wyoming and adjacent areas of Utah and Idaho where it is testing the Meade Peak shale.
As of December 31, 2012, the Company owned a 100% working interest in approximately 26,900 gross acres and 24,100 net acres in Gonzales, Karnes, LaSalle, Wilson and Zavala Counties and a 50% working interest in approximately 2,800 gross and 1,400 net acres in DeWitt County and are the operator of this acreage. It also owns an approximate 21% working interest in approximately 12,800 gross acres in Atascosa County operated by EOG Resources, Inc.
South Texas
The Company focuses on the exploration and development of its Eagle Ford shale properties in South Texas. During 2012, the Company completed and began producing oil and natural gas from 28 gross/24.5 net operated Eagle Ford shale wells, including 25 gross/23.7 net operated and 3 gross/0.8 net non-operated Eagle Ford shale wells. During 2012, 43% of its daily production, or 3,908 barrels of oil equivalent (BOE) per day, including 3,246 one stock tank barrel (Bbl) of oil per day and 4.0 one million cubic feet of natural gas (MMcf) of natural gas per day, was produced from the Eagle Ford shale in South Texas. During 2012, the Company drilled and completed a total of 32 gross/30.5 net Eagle Ford wells on its operated properties. As of December 31, 2012, its aggregate leasehold int! erests consisted of approximately 42,500 gross acres and 27,900 net acres in the Eagle Ford shale play in Atascosa, DeWitt, Gonzales, Karnes, LaSalle, Wilson and Zavala Counties in South Texas.
Northwest Louisiana and East Texas
During 2012, bout 56% of its average daily production, or 5,042 BOE per day, including 31 Bbl of oil per day and 30.1 MMcf of natural gas per day, was from its leasehold interests in Northwest Louisiana and East Texas. For the year ended December 31, 2012, about 76% of its daily natural gas production, or 26.0 MMcf of natural gas per day, was produced from the Haynesville shale, with another 12%, or 4.1 MMcf of natural gas per day, produced from the Cotton Valley and other shallower formations in this area. As of December 31, 2012, the Company had leasehold and mineral interests in approximately 22,300 gross and 14,200 net acres prospective for the Haynesville shale.
Advisors' Opinion: - [By Ben Levisohn]
Heading into today, Matador Resources (MTDR) had gained 40% so far this year, as the competitor to Anadarko Petroleum (APC) and EOG Resources (EOG) has boosted oil & gas revenue and oil production. Make that 32% after Matador Resources announced a secondary offering.
Top Asian Stocks To Own Right Now: Waste Connections Inc. (WCN)
Waste Connections, Inc., an integrated solid waste services company, provides solid waste collection, transfer, disposal, and recycling services. The company also offers intermodal services, including repositioning, storage, maintenance, and repair of cargo containers for international shipping companies for the rail haul movement of cargo and solid waste containers in the Pacific Northwest. In addition, it provides container and chassis sales and leasing services to its customers. Further, the company offers residential, commercial, and industrial solid waste collection services; and provides recycling services for various recyclable materials, including cardboard, office paper, plastic containers, glass bottles, and ferrous and aluminum metals. Its transfer stations receive, compact, and load solid waste to be transported to landfills via truck, rail, or barge. As of December 31, 2010, the company owned or operated a network of 135 solid waste collection operations, 54 t ransfer stations, 39 recycling operations, 44 active landfills, and 7 intermodal facilities, as well as one exploration and production waste treatment and disposal facility. It serves approximately two million residential, commercial, and industrial customers from a network of operations in 27 states in the United States. The company was founded in 1997 and is based in Folsom, California.
Advisors' Opinion: - [By Seth Jayson]
Calling all cash flows
When you are trying to buy the market's best stocks, it's worth checking up on your companies' free cash flow once a quarter or so, to see whether it bears any relationship to the net income in the headlines. That's what we do with this series. Today, we're checking in on Waste Connections (NYSE: WCN ) , whose recent revenue and earnings are plotted below.
Top Asian Stocks To Own Right Now: bluebird bio Inc (BLUE)
bluebird bio, Inc., incorporated on April 16, 1992, is a clinical-stage biotechnology company, the Company is focused on transforming the lives of patients with severe genetic and orphan diseases using gene therapy. Gene therapy seeks to introduce a functional copy of the defective gene into a patient�� own cells, a process called gene transfer. Through gene transfer, a functional copy of the mutated gene is delivered to the patient�� cells, thereby correcting the underlying genetic defect that causes aberrant gene expression. As of December 31, 2012, the Company is conducting a Phase I/II clinical study in France evaluating an earlier generation of its LentiGlobin vector for the treatment of �-thalassemia major and SCD. Initial proof-of-concept data from this study were published in Nature. During the year ended December 31, 2013, the Company plans to initiate an extension of this study under a revised protocol for LentiGlobin, which the Company refers to as the HGB-205 Study. The Company also plans o initiate a second Phase I/II clinical program in the United States for LentiGlobin, which the Company refers to as the HGB-204 Study, for �-thalassemia major. In March 2013, the Company entered into a strategic collaboration with Celgene Corporation, or Celgene, to discover, develop and commercialize, disease-altering gene therapies in oncology.
Its gene therapy platform is based on viral vectors that utilize a modified, non-replicating version of the Human Immunodeficiency Virus Type 1 (HIV-1) virus, that has been stripped of all of the components required for it to self-replicate and infect additional cells. The HIV-1 virus is part of the lentivirus family of viruses, as a result of which the Company refer to its vectors as lentiviral vectors. Its lentiviral vectors are used to introduce a functional copy of a gene to the patient�� own isolated blood stem cells, called hematopoietic stem cells (HSCs), which reside in a patient�� bone marrow and are capable of differentiating int! o a wide range of cell types. HSCs are dividing cells, thus its approach allows for sustained expression of the modified gene as the Company is able to take advantage of a lifetime of replication of the gene-modified HSCs. Additionally, the Company has developed a cell-based vector manufacturing process that is both reproducible and scalable.
Adrenoleukodystrophy
Adrenoleukodystrophy is a rare X-linked, inherited, neurological disorder that is often fatal. ALD is caused by mutations in the ABCD1 gene which encodes for a protein called the ALD protein (ALDP), which plays a critical role in the breakdown and metabolism of long-chain fatty acids (VLCFA). Without functional ALDP, VLCFA accumulate in cells including neural cells in which they cause damage to the myelin sheath, a protective and insulating membrane that surrounds nerve cells in the brain. This damage can result in decreased motor coordination and function, visual and hearing disturbances, the loss of cognitive function, dementia, seizures, adrenal dysfunction and other complications, including death. ALD is divided into various sub-segments with three main phenotypes that impact brain function: CCALD (Childhood cerebral adrenoleukodystrophy, AMN (Adrenomyeloneuropathy) and ACALD (Adult Cerebral ALD).
�-thalassemia
�-thalassemia is a rare hereditary blood disorder caused by a genetic abnormality of the �-globin gene resulting in defective red blood cells (RBCs). Genetic mutations cause the absence or reduced production of the beta chains of hemoglobin, or �-globin, thereby preventing the proper formation of hemoglobin A, which normally accounts for greater than 95% of the hemoglobin in the blood of adults. Hemoglobin is an iron-containing protein in the blood that carries oxygen from the respiratory organs to the rest of the body. Hemoglobin A consists of four chains-two chains each of a-globin and �-globin. Normally existing at an approximate 1:1 ratio, genetic mutations that impair t! he produc! tion of �-globin can lead to a relative excess of a-globin, premature death of red blood cells. The clinical implications of the a-globin/�-globin imbalance are two-fold: first, patients lack sufficient RBCs and hemoglobin to effectively transport oxygen throughout the body and can become severely anemic; and second, the shortened life span and ineffective production of RBCs can lead to other complications such as splenomegaly, marrow expansion, bone deformities, and iron overload in organs.
Sickle cell disease
Sickle cell disease (SCD) is a hereditary blood disorder resulting from a mutation in the �-globin gene that causes polymerization of hemoglobin proteins and abnormal red blood cell function. The disease is characterized by anemia, vaso-occlusive pain crisis (a common complication of SCD in which there is severe pain due to obstructed blood flow in the bones, joints, lungs, liver, spleen, kidney, eye, or central nervous system), infections, stroke, overall poor life and early death in a subset of patients. Under low-oxygen conditions, which are exacerbated by the red blood cell abnormalities, the mutant hemoglobin aggregates causing the RBCs to take on a sickle shape (sickle cells), which causes them to aggregate and obstruct small blood vessels, thereby restricting blood flow to organs resulting in pain, cell death and organ damage. If oxygen levels are restored, the hemoglobin can disaggregate and the RBCs return to their normal shape, but over time, the sickling damages the cell membrane and the cells fail to return to the normal shape even in high-oxygen conditions.
Advisors' Opinion: - [By Garrett Cook]
Bluebird Bio (NASDAQ: BLUE) shares shot up 33.61 percent to $34.86 following the presentation of positive data on LentiGlobin BB305 at the European Hematology Association (EHA).
- [By David Williamson]
In this video, health-care analyst David Williamson takes a look at the tremendous success of the�Bluebird Bio (NASDAQ: BLUE ) �IPO. The company increased the size of its initial public offering, and priced shares at $17 -- above the top end of its range -- but that still couldn't contain investor appetite for this stock. Shares shot up 50% on the opening day of trading, and have remained there.
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